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Metformin primarily reduces hepatic gluconeogenesis through the activation of AMP-activated protein kinase (AMPK), while sulfonylureas (e.g., glimepiride) enhance insulin secretion by closing pancreatic -cell ATP-sensitive potassium channels (Reuben et al., 2005
The scientists (including a team from the University of Leeds) assessed energy intake, ratings of appetite, thirst, nausea and wellbeing, control of eating, food preference, resting metabolic rate, body weight and body composition
Treatment recommendations depend on your individual goals and clinical review
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