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Serious side effects are rare when used under physician supervision with appropriate dosing

This makes the GCGR component particularly relevant for research into non-alcoholic fatty liver disease (NAFLD) models and energy balance studies

A recent cohort study demonstrated a significantly increased risk in psychiatric outcomes in patients prescribed GLP-1RA [155], while another study conducted on older adults with T2DM found a decreased risk of depression following GLP-1RA administration [156]