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Zhenqi Liu and former UVA graduate student Nathan Weeldreyer, found about 40% of the weight people lose using brand-name drugs like Wegovy or Zepbound comes from something called fat-free mass, which is everything in your body that is not fat

The appetite suppression and slowed gastric emptying caused by these drugs significantly impair both dietary vitamin D intake and absorption

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In the context of Retatrutide research, GCGR activation is studied primarily for its energy expenditure effects particularly increased thermogenesis and hepatic fat oxidation which add a distinct and significant metabolic dimension to the GLP-1R and GIPR incretin effects already present in dual agonists like Tirzepatide