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J Microbiol Immunol Infect

Indeed, melatonin is highly permeable to cell membranes and easily crosses the bloodbrain barrier 51 , ensuring a good therapeutic profile for brain diseases, and is also able to accumulate into mitochondria, probably via GLUT/SLC2A and PEPT1/2 carriers 52,53

21 If you have reduced HNMT activity, you're more likely to accumulate intracellular histamine, which means even if your DAO is working fine in the gut, you may still have problems clearing histamine in your brain (contributing to brain fog, nervousness, sleep issues) and airways (contributing to respiratory symptoms)

Whats clear in both these graphs is the reduced steady state average, compared to seven days dosing