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4a , on the other hand, was more resistant to the washout and inhibited CMFDA labelling up to 24 h (Supplementary Fig

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DMPK intestinal absorption research platform and parameters for oral drug evaluation Strategies for studying the intestinal absorption characteristics of drugs The oral drug development paradigm is evolving, with permeability becoming an increasingly important consideration for the successful development of oral candidates, especially for new chemical entities such as synthetic peptides and PROTACs (proteolysis targeting chimeras)