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Three Landmark Features The rationale for developing this multimodal supplement combination emerged from the Nottingham groups previous work which identified, three landmark metabolic features of hepatic steatosis: limited serine availability, reduced de novo glutathione (GSH) synthesis, and altered nicotinamide adenine dinucleotide (NAD+) metabolism. They hypothesized that supplementation with L-carnitine tartrate would facilitate mitochondrial fatty acid uptake from cytosol, while the NAD+ precursor nicotinamide riboside would induce hepatic mitochondrial -oxidation and facilitate mitochondrial fatty acid transfer
The trade-off is the extra step at home
NAC (N-Acetyl Cysteine) At typical oral doses of 600-1,800 mg/day, NAC is generally well tolerated
127,128,129,130 The resulting glutathione persulphide is a substrate for either persulphide dioxygenase, which oxidises the sulphane sulphur yielding sulphite and glutathione, or rhodanese, which generates thiosulphate
