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The longer effective tissue exposure is consistent with the actin-sequestration mechanism, which depends on intracellular accumulation rather than transient extracellular signaling

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Thus, the only piece of evidence lacking to draw a similar conclusion for GPX1 is a candidate M pro cleavage site , which most algorithms will fail to find, e.g., if they are highly stringent about requiring a Q in the P1 position (Figure 1)