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Treatment of HFpEF beyond the SGLT2-Is: Does the addition of GLP-1 RA improve cardiometabolic risk and outcomes in diabetic patients

PMID: 38741261.

Avoid compensatory behaviours such as vomiting, laxatives, diuretics, fasting after eating, or punishing exercise

The key difference is potency and duration: the natural hormone is quickly broken down by the body, whereas synthetic medications are much more resistant to breakdown, allowing them to stay active in your system for days or even weeks