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The levels of oxidized proteins decreased in ibuprofen treated male livers compared to controls, while not significant, a trend towards the increase in levels of oxidized proteins (P = 0.086) was observed in ibuprofen-treated female livers relative to controls

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Mean systolic blood pressure was increased in all PPA-treated groups compared to the control, but mean values for all 4 groups were within the normal range

They then performed 1:1 propensity score matching to create clinically comparable groups in three key analyses