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Clinical studies in humans have confirmed these animal findings

References Palmer SC, Tendal B, Mustafa RA et al (2021) Sodium-glucose cotransporter protein-2 (SGLT-2) inhibitors and glucagon-like peptide-1 (GLP-1) receptor agonists for type 2 diabetes: Systematic review and network meta-analysis of randomised controlled trials

WD consumption in middle-age, increased inflammation in the amygdala of females, and in the ventral hippocampus of males, whereas GE2 treatment reduced inflammation in the hippocampus and amygdala, depending on diet and sex