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The Lancet 397:22842303

The one piece of cleaner support is Sun 2021 (PMID 34827486), an independent group's APP/PS1 mouse study reporting improved Morris water maze performance, increased synaptophysin, and reduced IL-1/TNF- via PI3K/AKT

2.1 Hormonal factors Hormonal regulation is another important risk factor that plays a crucial role in breast cancer development, progression, and therapeutics ( Estrogen, a steroid hormone, is predominantly synthesized in ovaries until menopause and in adipose tissue post-menopause (43)