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Up-regulated expression of phospholipase C, 1 is associated with tumor cell proliferation and poor prognosis in hepatocellular carcinoma

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Since, the juvenile worms of Isoparorchis hypselobagri penetrate the intestine, liver and swim bladder before transforming into an adult stage, we hypothesise that the migrating juvenile worms cause tissue damage that could result in the down-regulation of antioxidant enzymes