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Figure 1 3 Holistic account of the mechanism of gutbone axis and molecules involved 3.1 Direct effect of gut factors on bone health 3.1.1 Microbe-derived components in bone homeostasis Intestinal factors act on bone either directly or through immune and endocrine transitions, with the direct role of SCFAs in influencing osteoclasts and osteoblasts being prominent

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Strengths of the study include the fact that all individuals initiated on semaglutide attended four routine follow-up visits, and data on HbA 1c were available at baseline and follow-up for all but one person in each group

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