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The main difference is how and how often theyre taken.Similarities: Both are FDA-approved Wegovy formulations Both use semaglutide as the active ingredient Both follow a gradual dose-increase schedule determined by a provider Side effects are generally similar and can be managed with provider support Differences: Wegovy pen: Taken as a once-weekly injection Wegovy pill: Taken orally once per day Your Shed provider will help determine which option may be appropriate based on your health history, preferences, and treatment goals