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Early studies from the late 1990s reported that supplementation at 12 grams per day improved mood and reduced fatigue in patients with major depressive disorder, as evidenced by reductions in Hamilton Depression Rating Scale scores by about 2030% over 48 weeks [5]

Some investigators analyze whole-brain homogenates, whereas others focus on specific regions such as cortex, hippocampus, or cerebellum, each characterized by distinct redox and metabolic profiles

In late 2025, the UK government confirmed it will raise NICEs standard threshold range to about 25k35k per QALY ( [3] ) ( [4] )