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GLP-1-based therapies and resmetirom operate through distinct and potentially complementary mechanisms: while resmetirom exerts direct hepatic effects by activating THR- to enhance mitochondrial function, reduce hepatic lipogenesis, and promote lipid oxidation specifically in hepatocytes, GLP-1 RAs and multi-agonists address the upstream metabolic drivers of MASLD including insulin resistance, obesity, and systemic inflammation

For the nearly 1 in 3 American adults who are overweight and the 2 in 5 adults who have obesity, losing weight is the best step they can take to improve their health, but its not an easy step

One notable approach involves the use of dibenzazepine (DBZ), a -secretase/Notch pathway inhibitor

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