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Signs of a B12 Deficiency: At levels only slightly lower then normal, a range of symptoms such as: Fatigue Lethargy difficulty walking (staggering and balance problems) depression poor memory breathlessness headaches pale skin Inadequate Absorption: The most common cause of vitamin B12 deficiency is inadequate absorption

43 Upon exposure to a series of stress conditions, such as DNA damage, oncogene activation, ribosomal stress, nutrient deprivation, and hypoxia, TD (AA residues 325356) is responsible for the tetramerization of full-length p53 (p53 functions as a tetramer in the process of DNA binding)

However, this should only be done under medical guidance

Christmann, A