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Other signs of a heart attack can include: discomfort at the center of the chest, lasting more than a few minutes pain or discomfort in the arms, back, neck, jaw, or stomach shortness of breath nausea lightheadedness sweating People assigned female at birth are more likely than people assigned male at birth to experience other symptoms, such as shortness of breath, nausea, or vomiting, alongside chest pain

Acknowledgements We acknowledge the use of cryo-EM facilities at the Advanced Center for Electron Microscopy, Shanghai Institute of Materia Medica, Chinese Academy of Sciences