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The efficacy and safety of the treatment with different combinations versus treatment with either agent alone has been investigated by different groups in large mulitcentral trials [95, 96]

[9] Cognition can also be affected in Wilson's disease, in two non-mutually exclusive categories: frontal lobe disorder (may present as impulsivity, impaired judgement, promiscuity, apathy, and executive dysfunction with poor planning and decision-making) and subcortical dementia (may present as slow thinking, memory loss, and executive dysfunction, without signs of aphasia, apraxia, or agnosia)

LDT Health Solutions and the Wells Pharmacy Network did not respond to requests for comment

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