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If three or more are out of range, your long-term risk rises

Banks and Kastin reported that radiolabeled DSIP administered peripherally produced detectable DSIP-like immunoreactivity in brain tissue at levels above what non-specific leakage would predict, and that the modified analogue [D-Ala3]-DSIP entered brain at substantially higher levels than the parent compound after intracarotid administration (Banks & Kastin, 1981)