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(iv) glutamine polarizes macrophages to M2 phenotype [183] and, as a precursor of glutamate, can also restrain macrophages function, after glutamate-induced N-methyl-D-aspartate receptor (NMDAR) channel activation, leading to tumor development in mouse models of fibrosarcoma and hepatocellular carcinoma [184]

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Losing weight too quickly could be a red flag for muscle loss and bone mineral density