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Lancet, 390(10103), 16641675

Similarly, specific inhibitors of the cancer protein myoferlin and WJ460 can trigger cell cycle arrest in the G2/M phase and upregulate mitophagy-related genes in PDAC cells, thereby leading to cell death due to excessive Fe 2+ and ROS levels [118]

Some researchers have shown that metformin activates AMPK and triggers the downstream GSH system to slow DOX-mediated oxidative impairment in the myocardium [225, 226]