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Dysregulation of carnitine metabolism in DKD In contrast to the tightly regulated carnitine homeostasis under physiological conditions, the progression of DKD disrupts the renal homeostasis of carnitine metabolismgoverned by synthesis, absorption, and excretionleading to significant regional heterogeneity and systemic metabolic dysfunction

A provider has pointed out, The biggest challenge is deciding whether to prescribe medication for patients with BMI near the 30% cutoff, as small variations in weight can significantly impact eligibility. Ethical dilemmas arise when patient expectations are set too high, balancing clinical appropriateness with patient expectations when data foundations are not trustworthy

Pages-Puigdemont N, Mangues MA, Masip M, et al