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Both Drugs Are Contraindicated In: Pregnancy (or if pregnancy is planned imminently) Personal or family history of medullary thyroid carcinoma (MTC) Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) Known hypersensitivity to the active ingredient or excipients Insurance and Prior Authorization Implications Switching from semaglutide to tirzepatide is a new prescription requiring new prior authorization

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Results from a clinical trial published in 2024 showed that weekly semaglutide injections were better than placebo at controlling blood sugar in people with prediabetes and obesity