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Patients should stop the medication and contact their healthcare provider immediately if they experience: Severe or persistent abdominal pain (especially if radiating to the back), which could indicate pancreatitis Persistent vomiting preventing adequate fluid intake Signs of dehydration (dark urine, dizziness, reduced urination) Yellowing of skin or eyes (jaundice) or pale stools Unexplained fever Severe diarrhoea lasting more than 48 hours Treatment continuation is reviewed regularly, with decisions based on efficacy, tolerability, and ongoing clinical need

Even though berberines lower concentration can be an asset in managing insulin resistance when combined with other lifestyle changes, its worth noting that it falls short of the maximally effective dosage

Or, you can take a polyphenol supplement

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