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Of particular interest, the discovery of GLP-1 receptor expression in the myocardium and in the vascular endothelium suggested possible roles of GLP-1 in the cardiovascular system and multiple preclinical studies support cardioprotective effects of native GLP-1 (Fig

Putting it all together: your personalized dosing decision After absorbing all of this information, here is how to synthesize it into a practical dosing plan for your specific situation

If the format holds, it would enable tissue targeting (liver-selective glucagon action, for example) that a free peptide cannot achieve

A provider who understands these differences may be willing to prescribe based on your actual metabolic risk rather than a standard BMI cutoff that was not designed for your population