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Meanwhile, the expression of NLRP3, Caspase-1, and IL-18 were obviously enhanced in TAC group, compared to the Sham group, but their expression in TAC + semaglutide group were remarkably lessened, compared to the TAC group, by Western-blot and IHC respectively

1 that it was discontinuing phase 3 clinical trials of the twice-daily version due to high rates of adverse side effects