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Although silencing the gene UL39 can limit the proliferation of oncolytic HSV-1 after injection, enhancing the safety of this oncolytic virus in clinical applications, the tumor-killing effect of this oncolytic virus is also restricted, requiring a larger dosage and multiple injections to achieve the desired effect

Interestingly, the deletion of NOX2 following mouse TBI (Wang et al., 2018) or PTZ-induced SE ( 2 and resulting increased steady-state H 2 O 2 levels is necessary for NF-KB activation in macrophages (Li et al., 2018) and for microglia proliferation (Mander et al., 2006)

They may work synergistically to enhance antioxidant support and overall wellness