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Starting doses typically begin low and gradually increase over several weeks to minimize gastrointestinal side effects like nausea, which are the most common complaint during the first few weeks of treatment

Clinician-managed dosing & follow-up slow titration and regular visits help manage GI and other side effects while optimizing dose

But the Ministry of Health stressed that the drugs can only be used with a doctors prescription

Lastly, although the use of analytical methods has aided in our deeper understanding of the relationship between drugs and ADEs, it must be emphasized that well-designed clinical trials remain crucial in establishing causal relationships, and further research needs to be conducted through extensive clinical studies