oxidized glutathione molecule, illustr | Stock Image no Glutathione disulfide (GSSG) is the oxidized form of glutathione (GSH) Glutathione (oxidized glutathione, GSSG) molecule.

Cancer Risk A review and discussion stated: ROS production is significantly increased in cancer cells because of mitochondrial dysfunction, altered metabolism, and frequent genetic mutations, resulting in an accumulation of large amounts of oxidized protein, DNA, and lipids as an adaptive response, cancer cells harbor elevated levels of ROS-scavenging molecules

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Thus, the presence of the thiol group of C32 in PfGrx seems to impair the glutathionylation and to facilitate the deglutathionylation of roGFP2

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