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Another early investigation published in the European Journal of Endocrinology documented that, unlike older GH-releasing peptides, such as GHRP-2 or GHRP-6, ipamorelins GH stimulation is highly selective and does not significantly increase cortisol or prolactin levels, suggesting a cleaner hormonal profile with fewer off-target endocrine effects compared to earlier secretagogues

Breeding of Gcgr null mice were in compliance with an animal experiment license issued by the Danish Committee for Animal Research and approved by the local animal welfare committee at the University of Copenhagen

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