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The observations in SUSTAIN-6 are predictable, given that intensified versus conventional insulin therapy is well known to have the capacity to precipitate initial worsening of retinopathy in patients with T2D with advanced preexisting retinopathy, as shown in the Diabetes Control and Complications Trial (82)

Studies have also shown that GLP-1 can significantly increase the expression of GLP-1R through G protein-coupled receptor 119 (GPR119), enhance the activity of ABCA1, lead to the increase of apo AI, and thus promote intracellular cholesterol outflow [73]

Amersi thinks patients can benefit from microdosing now, even without data to prove its efficacy, if they work with a doctor to carefully monitor their response

Ensure the healthcare professional has experience in comprehensive medical screening, insurance support, and ongoing follow-ups to handle side effects