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While moderate amounts can support gut and immune function, too much can thin this barrier, leading to increased intestinal permeability (leaky gut), inflammation, and immune dysregulation An overgrowth of Akkermansia is linked to Multiple sclerosis, Parkinsons disease, Colorectal cancer, and Autoimmune flares So while the idea of taking a probiotic to boost GLP-1, and therefore reduce appetite or support blood sugar, sounds promising, forcing the gut ecosystem out of balance can backfire

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Chronic hyperglycaemia, the production of reactive oxygen species (ROS), and the release of inflammatory cytokines are some of the factors causing endothelial dysfunction in patients with diabetes [11, 12]

Moreover, in a further study of the same group, the increased release of SELENOP from the choroid plexus to the CSF in Alzheimers disease patients was reported (Rueli et al., 2015)