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Compounded versions require patients to draw precise amounts from vials, which has led to reported administration errors where patients accidentally injected doses up to 10 times higher than prescribed, causing severe nausea, vomiting, abdominal pain, and weakness

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In company-reported late-phase maintenance data, patients in SURMOUNT-MAINTAIN first lost weight on higher-dose Zepbound, then either continued the maximum tolerated dose or stepped down to 5 mg for a maintenance year