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Interestingly, longer exposure times suppress GLP-1 release (Chimerel et al., 2014), which may be important in gut-brain signaling regulation
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Primary composite end point 2 : Time from randomization to first occurrence of a 3-part composite MACE, defined as CV death, non-fatal MI, or non-fatal stroke Key secondary end points 2 : Time from randomization to first occurrence of: Cardiovascular death All-cause death Other secondary end points 2 : Time from randomization to first occurrence of: Fatal or non-fatal myocardial infarction Fatal or non-fatal stroke Relevant supportive secondary end points 2 : Change in body weight from baseline to week 104 Change in waist circumference from baseline to week 104 Change in systolic blood pressure from baseline to week 104 Change in diastolic blood pressure from baseline to week 104 Change in heart rate from baseline to week 104 Change in A1c from baseline to week 104 Change in lipids from baseline to week 104 LDL, HDL, triglycerides, and total cholesterol
Int J Med All Body Health Res 3(1):6371 Olajide AT, Olayinka ET, Ore A, Kehinde SA, Okoye CC (2023) Ellagic acid alleviates pulmonary inflammation and oxidative stress in mouse model of diisononyl phthalate-induced asthma
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