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Satiety related gut hormones like GLP-1 and Peptide YY are also released from the enteroendocrine L-cells in the distal small bowel when exposed to nutrients to produce reduced eating

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In the canonical pathway of pyroptosis, intracellular pattern recognition receptors (PRRs) recognize PAMPs (Pathogen-Associated Molecular Patterns) or Damage-Associated Molecular Patterns (DAMPs), which can activate NLR family pyrin domain-containing 3 (NLRP3) and assemble with pro-caspase-1 and adaptor protein ASC to form inflammasomes

We will need results from ongoing Phase 3 trials and FDA approval to know: Long-term safety and effectiveness Cost and insurance coverage How it compares in real-world use to similar medications like semaglutide (Ozempic/Wegovy) and tirzepatide (Zepbound/Mounjaro) Sources Jastreboff, A