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Proactive hydration strategies can help patients taking GLP-1 receptor agonists maintain adequate fluid balance and minimize thirst-related discomfort
Protocatechuic acid ameliorates high glucose-induced extracellular matrix accumulation in diabetic nephropathy
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Headache, dizziness: Generally mild but can impact patient adherence
The dosing regimen varies depending on whether neurological symptoms are present: With neurological involvement: 1 mg intramuscularly on alternate days until no further improvement, then 1 mg every 2 months [3] [4] Without neurological involvement: 1 mg intramuscularly three times a week for 2 weeks, then 1 mg every 2-3 months for maintenance [3] [4] There is some evidence that high-dose oral B12 (1000-2000 micrograms daily) may be effective even in some malabsorption conditions, though UK practice still generally favours intramuscular treatment in these cases
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