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Compound 40 evicts TRF1 from the shelterin complex We developed a mass-photometry based assay to evaluate the ability of compound 40 to disrupt the TRF1 TRFH :TIN2 TBM interaction and subsequently evict TRF1 from the full shelterin complex

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Treatment with either thymalin or epithalamin decreased mortality by 1.6- to 2.1-fold, as compared to control subjects