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Methodology & quality box Synthesis & fill: EU laboratory standard, sealed vials, dose-validated per unit Identity: HPLC purity + MS confirmation, per lot Endotoxin: LAL result in EU/mg on lot CoA Traceability: lot number on vial maps to synthesis record, analytical files and shipping batch CoA access: issued per lot, available on request before dispatch Status: research use only

Caplan offers an important caveat: results in small clinical trials and results in the general population are often very different

The morning row is credited with allowing full-day symptom monitoring and consistent circadian alignment, offset by nausea during work or daily activities affecting comfort

therefore, interobserver variability was not assessed in this study