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Estrogenic activity of E2-conjugated GLP-1 is mediated by intracellular endolysosomal acidification and estrone metabolism

Midlife is an important window for longterm brain health Many health conditions that influence cognitive function later in life, such as obesity, high blood pressure, diabetes and changes in sleep, first appear or become more common during midlife (see Potentially Modifiable Risk Factors section starting on page 19)

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