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These percentages translate to 25 to 35 pounds for a 250-pound man, a level of weight reduction associated with meaningful improvements in metabolic parameters and quality of life

Journal of Bacteriology, 182 (4), 11581161

While individual IEMs are rare that typically become apparent clinically during the newborn period or early infancy, though milder and even asymptomatic forms may emerge in adolescence and adulthood