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Eli Lillys ATTAIN-1 trial showed an average weight loss of 14% over 72 weeks with the highest dose of orforglipron, containing 36 mg of the active ingredient

In the SUSTAIN 15 and 7 trials, once-weekly subcutaneous semaglutide consistently reduced HbA1c, improved Fasting Plasma Glucose and self-monitoring blood glucose profiles with a low risk of hypoglycemia in patients with T2DM

Unlike FXa-resistant PAR2-G37I mice, lean PAR2-K36E mice showed no difference in postprandial GIP levels, excluding a role for the matriptase-PAR2 axis in GIP regulation (Figure 1S)