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Previously, we showed that systemic exendin-4 penetrates the brain and distributes to the VTA where it is localized in proximity to Th+ neurons 8

For those taking 12mg, 100% lost at least 5%, 93% lost at least 10%, and 83% lost at least 15%

[DOI] [PMC free article] [PubMed] [Google Scholar] 71.Grasset E, Puel A, Charpentier J, et al

If you experience vomiting or severe diarrhea while taking oral contraceptives and tirzepatide, follow CDC guidance for missed pills: use back-up contraception if vomiting occurs within 2 hours of taking a pill, and consider emergency contraception if multiple pills are affected during the first or third week of the pack