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Given the evidence that a pulsatile pattern of secretion may be important for many of the physiological actions of GH, a strategy to augment physiological pulsatile GH secretion may be desirable and may have less effect on insulin sensitivity than rhGH

In fact, glucose sensors in the hypothalamus were first discovered in the VMH and LH [57, 58]

The STEP 5 trial showed that patients who stopped semaglutide after 68 weeks regained approximately 2 pounds per month over the following year, while those on maintenance therapy held steady

Both endogenous GIP (52) and GLP-1 (53) have very short half-lives, measured in minutes, resulting in only a small portion of these active hormones reaching the systemic circulation