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While generally considered safe for most people when taken as directed, berberine can cause some unwanted effects

[5] [6] Additionally, the medication slows gastric emptyingthe rate at which food leaves the stomachwhich prolongs the feeling of fullness after meals and reduces the desire to eat between meals

In another USA study, low annual household income was also associated with decreased odds of initiating a GLP-1 RA, whereas this association was not observed for DPP-4 inhibitors, likely owing to their lower out-of-pocket expenses compared with GLP-1 RAs [22]

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