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If constipation lasts more than a week, is accompanied by severe pain, blood in the stool, or unexplained weight loss, consult a healthcare provider promptly

Studies of osteoblasts have revealed that GPER activation not only promotes the proliferation and differentiation of osteoblasts, thus affecting bone mineralization via the AMPK/ACC signaling pathway, but also inhibits mitochondrial autophagy in osteoblasts through the activation of the AKT pathway, reducing apoptosis [146]

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[2] In SURPASS-1, Mounjaro (15 mg) demonstrated a mean weight reduction of 22.5% compared to 3.0% with placebo at 52 weeks