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Importantly, the lack of major modern human trials is itself informative

Because B12 injections are given intravenously, there are no barriers to absorption, and they can begin working within hours

The hormonal imbalances seen in females with PCOS are decreased follicle-stimulating hormone (FSH) and FSH/LH ratio, increase in the level of LH, fasting insulin, estrogen, free testosterone, and a mild increase in prolactin [4]