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In comparisons between tirzepatide and semaglutide, when HbA 1c was measured in mmol/mol, all tirzepatide doses were comparable with semaglutide 2.0 mg and superior to semaglutide 1.0 mg and 0.5 mg (ESM Table 6)

However, when the -carbon (the carbon adjacent to the nitrogen) in backbone-extended amino acids is replaced with oxygen, a more rigid conformation is observed (Figure a)