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Genotoxicity testing, which evaluates whether a compound can damage DNA, found no evidence that 5-amino-1mq causes genetic damage
Aging elevates NNMT in adipose and muscle tissues, disrupting metabolism
5A-1MQ-treated mice switched from WD to LD (WD/LD-T) showed a rather reduced relative abundance of Akkermansia compared to vehicle-treated DIO animals switched from WD to LD (WD/LD-V), suggesting a unique microbiome mechanism associated with weight loss in the vehicle-treated group switched from WD to LD compared to the 5A-1MQ-treated group that underwent the same diet switch
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