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10.3390/molecules30153111 74 WuH.XuC.YanY.PengM.DengT.YangX.et al (2025)

While HSPA5 upregulation can enhance GPX4 activity and inhibit lipid peroxidation, experimental disruption of this pathway (e.g., via siRNA) blocks DHAs protective effect, allowing its inherent ROS-generating capacity to prevail, ultimately inducing ferroptosis [73]